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摘要 骨关节炎(osteoarthritis,OA)是一种与年龄相关的慢性、进行性和退行性关节疾病,影响着全球数以千万计的中老年患者。其主要特征包括关节软骨退化、软骨下骨增厚、滑膜炎症和骨赘形成,主要症状是疼痛、僵硬和活动受限。它不仅给患者带来了巨大的痛苦,降低患者的生活质量,而且增加了社会经济负担。近年研究对OA表观遗传调控机制的关注,揭示了非编码RNA(non-coding RNA,ncRNA)在调节软骨细胞与细胞外基质平衡方面的潜在重要作用。
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基金资助:广东省中医院与香港中文大学医学院生物医学学院基础临床协同创新计划项目(YN2018HK04) |
通讯作者:
曹学伟
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作者简介: 李震(1993- ),男,研究生在读,广州中医药大学,1227258179@qq.com |
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