Abstract：Objective To investigate the factors involved in delayed vertebral union after PKP in patients with OVCF.Methods This retrospective case-control study enrolled patients who had been treated using single-segment PKP from January 2011 to January 2012.Demographic and surgical data were collected to analyze the risk factors associated with delayed vertebral union after PKP.Results A total of 580 patients with OVCF treated with PKP were enrolled in the study.Of these，29 (5.0%) had experienced delayed vertebral union and they were paired with age-and sex-matched patients who experienced vertebral union.Multivariate analyses revealed that a low preoperative bone mineral density (OR 0.114，95% CI 0.014～0.900)， the presence of an intravertebral cleft (OR 35.88，95% CI 1.690～762.034)，and a higher restoration rate of vertebral height (OR 4.053，95% CI 1.217～13.496) were independently associated with delayed vertebral union.Conclusion Preoperative BMD，intravertebral cleft，and restoration rate of vertebral height appear to be risk factors for delayed vertebral union after PKP in patients with OVCF.
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