Abstract:Objective To explore the perioperative hemodialysis strategy of uremia patients undergoing total hip arthroplasty.Methods This study was a retrospective analysis.74 patients with uremia who were admitted to the joint surgery department of Changzheng Hospital Affiliated to the Naval Military Medical University from June 2006 to June 2017 were selected as the study objects.Heparinfree hemodialysis was performed in the control group 1 day before surgery and on the first day after surgery.The study group was used low molecular weight heparin hemodialysis 1 day before surgery and on the first day after surgery.The renal function,hemoglobin reduction,blood coagulation index and joint function recovery of the two groups were observed and compared.Results All patients were followed up for 13~102 months,with an average of (34.5±6.8) months.The indexes of blood urea nitrogen,blood potassium and blood creatinine in the study group were better than those in the control group (P<0.05).There were no significant differences in the Harris scores of coagulation function,bleeding volume and hip joint function after surgeries between the two groups (P>0.05).Conclusion For uremic dialysis patients,there was no significant difference in postoperative bleeding,blood coagulation,and joint function recovery between heparin-free hemodialysis and low-molecular-weight heparin hemodialysis during total hip arthroplasty.However,the renal function of patients with low molecular weight heparin hemodialysis is significantly better than that of patients without heparin hemodialysis.This suggests that for patients with uremia who require total hip arthroplasty,low-molecular-weight heparin hemodialysis is recommended during the perioperative period,which helps to protect patients' renal function,improve the safety of surgery,and reduce the risks.This deserves to be widely used in clinical practice.